CBD, what is it?

 

CBD, or cannabidiol, is a chemical compound from the cannabinoid family that naturally occurs in the cannabis plant. Scientists have isolated 108 different types of cannabinoids in cannabis.

Delta-9-tetrahydrocannabinol, or THC, is probably the best-known thanks to its psychoactive properties — it’s the one that gets you “high” — but CBD is quickly gaining ground due to its potential therapeutic benefits.

How does CBD work?

CBD (and THC) work by interacting with our body’s endocannabinoid system, a regulatory system made up of naturally occurring cannabis-like molecules. These endocannabinoids, as they’re called, work like neurotransmitters, shuttling messages through the body to help maintain homeostasis. Cannabinoids like CBD and THC interact with the endocannabinoid system at two known receptors: CB1 and CB2.

CB1 receptors are mainly present in the brain — where they’re involved with cognition, memory, motor skills and pain — but also in the peripheral nervous system, liver, thyroid, uterus and more. THC attaches itself to these receptors, inhibiting the release of neurotransmitters and possibly increasing the release of others, altering normal functioning.

molucular structure of CBD

Researchers once thought that CBD did the same thing, but with CB2 receptors — which are abundant in the immune and gastrointestinal systems, as well as the brain and nervous system. However, they no longer believe that to be true.

Although the exact way CBD affects our bodies is still unknown, scientists think CBD encourages the body to produce more of its own endocannabinoids, which may help reduce anxiety, pain and inflammation.

Is CBD legal?

Technically yes, but the answer isn’t quite so cut and dried.

The cannabis plant comes in many different varieties. For decades though, the US Drug Enforcement Administration (DEA) treated them all the same, classifying cannabis as a Schedule I substance. Schedule I drugs are considered to have “no currently accepted medical use and a high potential for abuse” and are thus illegal to produce or possess.

However, the Agriculture Improvement Act of 2018 (aka the Farm Bill) changed all that. The Farm Bill legalized “hemp,” which the legislation defined as cannabis that contains no more than 0.3% THC, nationwide.

Cannabis that contains higher levels of THC is now listed as “marijuana” and remains a Schedule I drug. 

In other words, if a CBD product comes from a hemp plant, it’s legal; if it comes from a marijuana plant, it’s federally illegal, despite local laws. And even if it does come from a hemp plant, there’s often no guarantee it won’t contain THC, thanks to things like cross-pollination and the absence of industry regulation (see “What are the risks of taking CBD?” below).

The Food and Drug Administration is currently trying to figure out how to regulate CBD, which now falls under their purview. But in the meantime, experts recommend buying CBD products from companies located in states like Indiana and Utah that require cannabis products to be tested for potency and purity.

What are the health benefits of CBD?

CBD is being marketing as a bit of a cure-all, with manufacturers claiming it can do everything from relieving anxiety to stopping the spread of cancer. However, cannabis’s classification as a Schedule 1 drug has severely hampered American scientists’ ability to study CBD, making it hard to support or refute these claims. The studies that are available tend to be small or are done on animals or in laboratories.

That said, CBD is showing promise. Early experiments suggest that it may help fight anxiety, ease schizophrenia symptoms and reduct pain (though the latter is often done in conjunction with THC).

The strongest evidence of CBD’s effectiveness, though, is in relation to epilepsy. Last year, the FDA approved Epidiolex, a medication used to treat Lennox-Gastaut and Dravet syndromes, two rare and severe forms of epilepsy. It was the agency’s first approval of a cannabis-derived drug.

How is CBD used?

CBD is available in a variety of forms. Some of the most common CBD delivery methods are listed below, but how it’s ultimately used depends on personal needs and preferences. The delivery method of CBD affects how quickly it works and what kinds of effects it has on the body.

  • Edibles are broad range of products to eat or drink, like gummies or chocolates. Edibles can take anywhere from 20 minutes to four hours to take effect.
  • Oils and tinctures are processed and concentrated forms of CBD that are often placed under the tongue using a dropper and absorbed into the bloodstream.
  • Pills and capsules are ingested orally and look similar to the vitamins and/or drugs you’d find in a drugstore. They typically contain CBD oil or CBD isolate.
  • Topicals are CBD-infused oils, creams and lotions that are intended to be used directly on skin, hair or nails. They’re a popular way to treat localized pain, but are also used as skincare, haircare and massage oil as well.
  • Vaping, like e-cigarettes, involves inhaling a vaporized liquid that contains CBD oil. Nicotine is not usually present if CBD is, though it is possible to mix them.